What is GHK-Cu (Copper peptide)
Copper Peptide not only stimulates blood vessel and nerve outgrowth, but it also enhances the presence of collagen, glycosaminoglycan synthesis, and elastin within the body.
GHK-Cu can also improve tissue repair in the skin, liver, lung connective tissue, stomach lining and it also supports the function of dermal fibroblasts.
Adults in their 20s possess 200mg/ml of this copper complex, while adults in their 60s only have 80ng/ml, indicating that the levels of Copper Peptide GHK-Cu drop during the aging process.
Recent studies show that GHK-Cu has the ability to regulate biochemical pathways resulting in diverse healing and protective actions. Not only does Copper Peptide stimulate blood vessel and nerve outgrowth, but it also enhances the presence of collagen, glycosaminoglycan synthesis, and elastin within the body. GHK-Cu can also improve tissue repair in the skin, liver, lung connective tissue, stomach lining and it also supports the function of dermal fibroblasts.
Copper Peptide GHK-Cu also referred to as glycl-l-histidyl-l-lysine peptide is a copper complex that is naturally produced in the human body, it has a strong affinity for Copper(ll) and is composed of three amino acids that are found in human blood plasma, saliva, and urine.
Copper Peptide is essential to various biological functions in the body, such as accelerating wound repair, promoting blood vessel outgrowth, anti-tumour defence, as well as, antioxidant and anti-inflammatory effects.
The medical study of Copper Peptide GHK-Cu began 48 years ago in the 1970s, since then medical researchers have made ground breaking discoveries regarding its molecular actions and biological processes.
Copper is a transitional metal that is critical to human survival.
It operates as an extraordinary factor in a plethora of biochemical reactions.
GHK-Cu’s unique ability to bind with Copper ions makes it an important role in copper metabolism. The relationship between Copper ions and Copper Peptide GHK-Cu allows GHK-Cu to modulate gene expression and regulate human genes.
In 1994, doctors discovered that the application of a 2% GHK-Cu gel on diabetic patients was enough to enhance the percentage of ulcer closure from 60.8% to 98.5% and decrease the percentage of infections from 34% to 7%.
Numerous controlled facial studies confirm that Copper Peptide is an essential element that can be used to firm and tone skin, likewise, reduce wrinkles and the facial aging process Doctors found that GHK-Cu amplified collagen in the photoaged skin and demonstrated remarkable improvements in skin laxity, clarity, and overall appearance.
Further clinical studies highlight the efficiency of synthetic analogue found in Copper Peptide used to stimulate hair growth.
Researchers believe that the presence of Copper Peptide in the body can stimulate the proliferation of keratinocytes and increase the expression of integrins and P63 protein in the epidermal stem cell resulting in its ability to revive proliferative prospects of epidermal stem cells and heighten their ability to repair tissue within the body.
Benefits of Copper Peptide GHK-Cu
Copper Peptide is a small molecule that holds many health benefits such as:
- Skin Restoration
GHK-Cu is a key ingredient in cosmetic products used to reduce the signs of aging by firming, toning and tightening the skin. Increases density removing deep wrinkles and lines on the face. Reduces skin spots. Lesions, mottled hyperpigmentation and improve the overall skin appearance.
- Stimulate Wound Healing
GHK-Cu is produced naturally in the body. It is found in human plasma and is released from the tissues when physical injuries occur. It’s regenerative properties and anti-inflammatory effects accelerate wound repair and healing. Patients are encouraged to use GHK-Cu after surgery to reduce scarring and advance the healing process.
3.Reduce Pain, Aggression, and Anxiety
Apart from its antioxidant and anti-inflammatory effects, GHK-Cu physical structure resembles Cimetidine, a component that is used to reduce pain.
- Hair Growth
As mentioned earlier, Copper Peptide GHK-Cu strongly stimulates hair growth by increasing follicle cell proliferation and decreasing programmed follicle cell death. The efficiency was measured to be similar to that of 5% Minoxidil
- Anti-Cancer Effects
GHK-Cu is capable of reversing the expression of specific genes associated with the metastatic spread of colon cancer even at a low dose.. Up to 70% of genes involved in the development of aggressive metastatic form of colon cancer was suppressed indicating GHK is capable of the regulation of various biological pathways on a gene level and it seems to be resetting the gene activity back to health leading to improvement of tissue repair
- Stem Cell
In 2009 researchers found GHK-cu stimulated proliferation of keratinocytes and increased expression of integrins and P63 protein in the epidermal stem cells. P63 is an important
marker to stem cells. GHK copper is able to revive the proliferative potential of epidermal stem cells and the ability to repair tissue.
- Nerve Regeneration
GHK -cu studies have shown its ability to increase the rate of regeneration of myelinated nerve fibres
- Human Fibroblasts
GHK-cu is established to be able to restore function of human fibroblasts damaged by radiation treatment by accelerating the healing and regenerative processes
- DNA Repair
GHK was able to restore viability of irradiated fibroblasts. The researchers used cultured human fibroblasts obtained from cervical skin that was either intact or exposed to radioactive treatment.
Fibroblasts are central cells in both wound healing and tissue renewal processes. They not only synthesize different components of dermal matrix, but also produce a number of growth factors that are involved in a multitude of cellular pathways regulating cell migration and proliferation, angiogenesis, epithelialization, and so forth. Radiation damages cell DNA, thus impairing their function.
Since GHK was able to restore function of irradiated fibroblasts, it has to have effects on DNA repair.
It has long been accepted that the human copper-binding peptide GHK-Cu enhances healing of dermal wounds and stimulates skin renewal exhibiting a wide range of effects. Cellular pathways involved in dermal repair and skin regeneration form an intricate and finely orchestrated biochemical network, where various regulatory molecules are involved in a cross-talk. When such an interaction is disrupted, the healing is delayed and may result in excessive inflammation and scarring. It appears that GHK is able to restore healthy functioning of essential cellular pathways in dermal repair through resetting the gene pattern to a healthier state. The molecule is very safe and no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies.
In conclusion, Copper Peptide GHK-Cu has been studied by doctors and researchers worldwide for over 40 years. Its biological effects have been proven through research studies and clinical trials on humans, as well as vivo lab. GHK-Cu is naturally produced by the human body and is safe to administer as a serum or microneedle treatment.
It’s antioxidant and anti-inflammatory effects, as well as, its ability to amplify collagen, elastin and glycosaminoglycan synthesis, repair tissue and regulate human genes makes it a prominent medical breakthrough
This drug has not been reported to have any side effects.
Suggested Dosage and Frequency of use for GHK-Cu is once a day for ten days with a dosage of 1- 4mg injected into the body fat around the stomach area or into the muscle